Usp purified water microbial specification This culture medium complies with the specifications given by EN ISO 10272-1/-2, ISO 17995, APHA, and with the specifications given by the 76 4. Pathogen testing of purified water: Analyze the sample of purified water for pathogens using filtration technique/Direct as per the current specification of Purified water. . 2 Drinking-water 3. 3 mS/cm ? The live version of this recording took place on April 21 - 22, 2021. 2) Production involves distillation, ion exchange, or reverse osmosis from water meeting regulatory standards, with storage/distribution preventing microbial growth and USP 41–NF 36, First Supplement. It boiling. Collentro 1. However, for microbiological testing, the compendia provide little guidance and do not include microbiological specifications. Product Specifications Test Specification USP Water Conductivity * USP <645> < 1. For SPECIFICATION OF PURIFIED WATER AS PER USP/BP/IP Purified water very useful and largely in the pharmaceutical Aid (solvent) production pharma industrial as preparation of tablet capsule liquid Ointment and parental preparation Purified water also to be use for all test and Assay and volumetric solution. The USP General chapter <1231> includes some of the chemical and microbiological concerns unique to water and its preparation and uses. usp. USP Mannitol RS; Polyoxyl 40 Hydrogenated Castor Oil. Summarize the requirements for purified water, water for injection and other USP water monographs, including specifications, testing, and Shop USultra USP Purified Water (USP-PW) at Thomas Scientific, your trusted partner in Science. Meets these specifications: USP Water Conductivity, USP 645 (at manufacture) USP Total Organic Carbon, USP 643 < 0. ] USP Sucrose RS H 2O 18. Purified Water Specifications (General Guidelines) According to various pharmacopeias (e. Bulk purified water 80 4. 1. Carry out the chemical analysis of samples as per the current version of purified water specification. For such purposes use USP Reference standards Get FAQs about water for pharmaceutical and analytical purposes The United States Pharmacopoeia (USP) has three general specifications for water quality that are applicable to medical and pharmaceutical uses, namely ‘USP Water for Injection’ (WFI), ‘USP Purified Water’, and ‘Drinking Water’. Manufacturing process: Softening of water, reverse osmosis, electrodeionisation and ultrafiltration. USP Chapter <1231> 7 – “Water for Pharmaceutical Purposes R2A is usually used for conducting microbial counts of purified water system Action Levels in USP <1231> (100cfu/mL for Purified Water and 10cfu/100mL for Water for Injection) are generally considered to represent a level above which the water is unfit for use. pressure. To avoid ever exceeding a water microbial specification USP 35 Official Monographs / Water5041 ADDITIONAL REQUIREMENTS preparations and in tests and assays unless otherwise speci- • PACKAGING AND STORAGE: Preserve in single-dose glass or fied (see 8. 0 ml for other USP 42 chapter 1231 - Free download as PDF File (. That is why an OOS investigation must be undertaken if those Action Levels are exceeded. This review article discusses the microbial contamination risk factors presented in USP General Informational Chapter Microbiological Examination of Non-sterile Products: Acceptance Criteria for Pharmaceutical Preparations and Substances for Pharmaceutical Use and other pertinent USP chapters when evaluating non-sterile drug products for objectionable Because there is potential for microbial contamina-water provider. 3. ), as well as the United States Pharmacopoeia (USP) and the Chinese Pharmacopoeia [Note—For microbiological guidance, see Water for Pharmaceutical Purposes . 0 Procedure – Microbiological Analysis of Water: Microbiologist shall collect the sample of water as per sampling plan following SOP – Sampling of Water for Testing. The European Pharmacopoeia (Ph. AquaPur Purified Water is designed to meet USP/EP specifications, and can be used for packaging, laboratory or production applications. 0, 10/17, EF 1 Meets stated value at the time of manufacture. Theoretically pure water has a balanced pH of exactly 7. 0 PURPOSE: To lay down a procedure for analysis of water samples (Chemical and Microbiological Analysis) 2. The exact nature of the testing is determined by the specification claimed for the water system, i. RECENT CHANGES 23 Purified Water test limits 2 1. 3 umhos/cm* UPS Total Organic Carbon USP <643>, EP < 0. Where used for sterile dosage forms, other than for parenteral administration, process the article to meet the requirements under Sterility pH is measurement expressing the acidity or alkalinity of a solution. 3 μS/cm at 25°C (United States Pharmacopeia – Published on Herbal Medicines Compendium (https://hmc. These concepts include specification, design, operation, testing, and maintenance of equipment and systems for water Introduction Pharmaceutical-grade purified water, often referred to as Purified Water (PW), is a critical component in pharmaceutical manufacturing and must meet stringent quality standards set by United States Pharmacopeia Oxidizable substances— To 100 mL, add 10 mL of 2 N sulfuric acid, and heat to boiling. 02 DEFINITION Add 10 mL of 2 N sulfuric acid, and heat to U. Total Aerobic Microbial Count: ON receipt of water sample for microbiological analysis define the specifications of purified water. Purified Water [Note—For microbiological guidance, see USP general information chapter Water for Pharmaceutical Purposes 1231 . Environmental Protection Agency National Primary Drinking Water Regulations or with the drinking water regulations of the European Union or of Japan, or with Analyze the Chemical samples (Raw water and Purified water) as per specification. According to drug Act is produced by distillation For purified water systems, microbiological specifications are not as clear. Drinking water is the required feed water to the purification system Sucrose RS. 2 Drinking-water is unmodi"ed except for limited treatment of the water derived from a natural or stored source. Purified water systems must be validated to reliably and consistently produce and distribute water of acceptable chemical and microbiological quality. Purified Water Specification As Per Usp, Pharmaceutical Water System Design Operation And Validation Pdf, A microbial specification would also be inappropriate when related to the “utility” or continuous supply nature of this raw material. Enumeration method, culture media, incubation temperature, and incubation time period must all be considered. PRODUCT SPECIFICATION SHEET PURIFIED WATER Meets USP Monograph 0. Purified Water must meet the requirements for ionic and organic chemical purity and must be protected from microbial Microbiology test of water ( IP,BP,USP) OBJECTIVE Microbiological Test of Water is provided to determine compliance with the requirements given in individual monograph/specifications. 45 um, using R 2 Agar and incubated at 30 – 35 ºC for 5 days, is an appropriate action level. Goal The following application note describes the three stages of (USP Microbiological Attributes Chapter . Implementing rapid microbial detection methods alongside traditional plate count techniques can further minimize risks and delays associated with bioburden control grab sampling. , USP, Ph. 1 mS/cm 1. Procedure for Water Analysis (Chemical & Microbiological) 1. for the To ensure adherence to certain minimal chemical and microbiological quality standards, water used in the production of drug substances or as source or feed water for the preparation of the various types of purified waters must meet the requirements of the National Primary Drinking Water Regulations (NPDWR) (40 CFR 141) issued by the U. 2 mL of 0. S. We note that USP <1231> does not include a recommendation for water microbiologic count for solid oral dosage forms Water conductivity, ultrapure water (UPW), USP<645>, water quality, dissolved ions, USP Purified Water (PW), Water for Injection (WFI), conductivity calibration kit, meter for conductivity. g. 1111>)There are no clear microbiological specifications for purified water systems. -To confirm the appropriateness of critical parameters and the operating ranges. Samples for TOC shall be analysed using TOC Instrument as per SOP; Note: On unscheduled breakdowns and holidays, samples from the stipulated sampling points shall not be collected for the week. Where used for the preparation of parenteral solutions subject to final sterilization, use suitable means to minimize microbial growth, or first render the Water for Injection sterile and, thereafter, protect it from microbial contamination. Made via deionization, reverse osmosis, UV treatment, and ultrafiltration, AquaPur meets specification including microbial specification through its 2 yr shelf life. 1 ml in three plats and 1. Pharmacopoeial specifications 78 4. 1 The sample under test comply with microbiological standards if the results comply with the alert limits for TVC and Each location shall prepare factory specification for raw water, potable water, after mix bed purified water and purified water referring Plims corporate specification and attachment-9 and 10. Procedure for chemical testing and microbiological testing of Raw/Tap water, RO water, and purified water samples. 1 N potassium permanganate, and boil for 5 minutes. Where used for sterile dosage forms, other than for parenteral administration, process the article to meet the requirements under Sterility Action Levels in USP <1231> (100cfu/mL for Purified Water and 10cfu/100mL for Water for Injection) are generally considered to represent a level above which the water is unfit for use. 2 ppm Purified Water— Purified Water (see USP monograph)is used as an excipient in the production of official preparations;in pharmaceutical applications,such as cleaning of certain equipment;and in the preparation of some bulk pharmaceutical chemicals. The scope of this protocol is to verify the Purified water system for the following boundaries and establish the operating ranges and procedures. 2 ppm), aluminum (maximum 10 ppb for dialysis solutions), and bacterial endotoxins (less than 0. 03. 34. The tests for Total organic carbon and Conductivity apply to Purified Water produced During your inspection, determine the source of the water used for wet granulations or for any aqueous liquid preparations as well as for the laboratory. To satisfy the microbiological and endotoxin quality component we are able to perform: Trust official USP Reference Standards, Pharmaceutical Analytical Impurities <11> USP Reference Standards <61> Microbiological Examination of Nonsterile Products: Microbial Enumeration Tests Sterile Purified Water; Mannitol. When tested as described above, European The specifications for EP water include various parameters on total organic carbons, nitrates, chlorides, microbial limits, and oxidisable substances. Analyze the microbiological samples as per SOP. Sampling Precautions – Purified Water: procedures, including any changes (21 CFR 211. 2018 Tanja Natterer cleaning agent. As purified water in inherently neutral, pH testing is recognized to be redundant to the USP 29 The specifications for various types of pharmaceutical-grade water according to the United States Pharmacopeia (USP) are presented in the tables below. Quality: This water produced and tested to meet or exceed USP-PW standards, each lot is quality tested for sterility, endotoxin, conductivity, pH and USP Chemical Analysis Expert Committee [Incl. 3 mS/cm 5. Purified water systems that function under ambient conditions are particularly susceptible to the establishment of tenacious biofilms of Microbial guidelines are provided under the informational chapter Water for Pharmaceutical Purposes <1231> where it states that the user should establish in-house For such purposes use Water for Injection, Bacteriostatic Water for Injection, or Sterile Water for Injection. It is prepared from USP Standards for Packaged Purified Water, Water for Injection, and Sterile Purified Water (USP24 effective 1/1/00). S. Purified water must not contain any Gram-negative bacteria. It should also be protected from recontamination and microbial proliferation. Water quality specifications 77 4. e. Maintaining the microbiological quality of HPW during distribution and storage 3. 22 micron filtered Main Catalog #: zp232000USP-Size Code* Microbial Limits ≤10 cfu/mL ≤1 cfu/mL Residual Solvents Meets the Requirements No solvents are used in manufacturing process Form: Water, USP, Rev 1. 0 [Note—For microbiological guidance, see Water for Pharmaceutical Purposes <1231> [1]. Good practices for water systems 85 8. This presentation is a summary of this chapter & provides information about Water quality attributes information that may or may not be included within a water monograph Processing techniques that can be used to improve water quality Microbial enumeration tests in water fall under the guidance of USP 1231. 02 Accelerated Revision Processes, USP publishes proposed revisions to the United States Pharmacopeia and the National NOTE— Purified Water is intended for use as an ingredient the requirements under Sterility Tests á71ñ,or first render the Purified Water sterile and thereafter protect it from microbial contamination. tion and other quality changes in this bulk packaged non-sterile water, this form of Purified Water should be prepared and stored in a fashion that limits microbial growth and/or TYPES OF WATER is simply used in a timely fashion before microbial prolifera- 6. NOTE— For microbiological guidance,see general information chapter Water for Pharmaceutical Purposes á1231ñ. Compiled by: 13. We can not provide To ensure adherence to certain minimal chemical and microbiological quality standards, water used in the production of drug substances or as source or feed water for the preparation of the various types of purified waters must meet the requirements of the National Primary Drinking Water Regulations (NPDWR) (40 CFR 141) issued by the U. 1 Drinking-water should be supplied under continuous positive pressure in a plumbing system free of any defects that could lead to contamination of any product. org) Purified Water Final Authorized Version 1. Purified Water USP, EP, etc. Production of Purified Water - pyrogen-free Water, Water for Injection (WFI) and Clean Steam to international pharmaceutical standards is widely recognised as a critical process. Eur and USP (EP/USP) Japanese Pharmacopoeia (JP) In house specifications; The chemical water quality of WFI is comparable with Purified Water, however, the difference lies in the endotoxin specification. The pH scale is logarithmic, and values less than neutral are more acidic and higher values are more basic. */USP*,** product code: 219 *current version **It is the user’s responsibility to ensure fitness for use of this packaged article when it is used in manufacturing, clinical or analytical applications where the purer bulk form of the water is indicated. Sterile Purified Water • USP REFERENCE STANDARDS〈11〉 USP 1,4-Benzoquinone RS [NOTE—For microbiological guidance, see Water for Pharma-USP Endotoxin RS ceutical Purposes 〈1231〉. In spite of the fact that the purity of water used in the cosmetic manufacturing is not specified by regulation, many cosmetic manufacturers have now committed to using Purified Water. Environmental Protection NOTE— Purified Water is intended for use as an ingredient of official preparations and in tests and assays unless otherwise specified (see Water in Ingredients and Processes and in Tests and Assays under General Notices and Requirements). Therefore, pharmaceutical water testing is critical to the quality control of the pharmaceutical Action Levels in USP <1231> (100cfu/mL for Purified Water and 10cfu/100mL for Water for Injection) are generally considered to represent a level above which the water is unfit for use. Although microbiological testing is also used to determine the presence of organic molecules in water, neither test may be used as a substitute Purified water for pharmaceutical purposes must be free of microbial contamination and pyrogens. USP24 contains complete versions of all pharmaceutical water monographs p. Ready to Ship. 5. Data Sheet -100214. Eur. 100(a)). 5 mg/litre is the USP limit. 4. 2. USP XXII specifications, that it complies with federal Environmental Protection Agency regulations for drinking water At the opposite end of the spectrum, many cosmetic manufacturers are now using USP Purified Water, which is water that meets the minimum purity standards for nonsterile drug manufacturing. 2201). However, it is left to the manufacturer to assess their product, its manufacturing process and establish an acceptable action limit of contamination and stay within the limits for the water system based on the highest risk product manufactured with water. It contains no antimicrobial agents. Download Table | Purified Water Standard Requirements from publication: The Application of Six Sigma in Process Control of Raw Water Quality on Pharmaceutical Industry at Indonesia | Quality is Harmonized tests covering both Ph. org USP-NF: Microbial Requirements in <1231> Water for Pharmaceutical Purposes. Microbial specifications are typically assessed by test methods that take at least 48 to 72 hours NOTE— Water for Injection is intended for use in the preparation of parenteral solutions. 1 N potassium permanganate, and boil for 5 minutes; where the fill volume is 50 mL or more, add 0. 5ppm This course will cover the principles of design and operation of water systems used directly in pharmaceutical manufacturing and laboratory applications, including the essential concepts and principles of systems used to generate USP and non-compendial waters. For PW, USP guidelines require a conductivity limit of 0. 230. These » Sterile Purified Water is Purified Water sterilized and suitably packaged. It contains no antimicrobial agent. Containers: 1 L, 5 L, 10 L, 20 L, 1000 kg brand new polyethylene containers with tamper [Note—For microbiological guidance, see Water for Pharmaceutical Purposes <1231> [1]. 02 DEFINITION Purified Water is water obtained by a suitable process. NOTE— Water for Injection is intended for use in the preparation of parenteral solutions. More stringent microbiological quality standards may be appropriate for other dosage forms [footnote references USP <1231>]. 5. 50 ppm Oxidizable Substances USP, EP Meets Requirements Microbial Contamination USP/EP Harmonized < 100 cfu/mL Water Conductivity* EP Meets Requirements* Acidity or alkalinity EP Passes Test Ammonium EP < 0. For Sterile Purified Water in containers having a fill volume of less than 50 mL, add 0. Upon completion of this course, you will be able to: Explain the importance of source water quality and pre-treatment concerns. General considerations for water purification systems 83 6. Specially designed to meet the rigid USP Purified Water (USP 1231) requirements of the Pharmacy Industry, the PharMate 4700 is relied upon by Pharmacies nationwide to produce purified, high-quality water for use in reconstituting oral medications. Water System You have not shown that your water system can for drug manufacturing, and, at a minimum, meets the USP purified water The PharMate 4700 USP Purified Water System represents the ultimate design and technology among water purification products. Proprietary manufacturing process ensures AquaPur Purified Water maintains microbial specification through expiration date. It is prepared from Microbial enumeration tests in water fall under the guidance of USP 1231. USP Sterile Purified Water ; (TOC) is an indirect measurement of organic molecules within water. Environmental Protection Levels may include alert, action and a specification as required in the current USP. To avoid ever exceeding a water microbial specification The minimum requirements for USP Pure Steam are those found in EPA/EU/WHO Drinking Water standards. It should be of USP purified water Sterile Purified Water is Purified Water sterilized and suitably packaged. Bulk water for injections 81 4. 0 MICROBIAL LIMIT TEST TOTAL AEROBIC BACTERIAL COUNT: Media preparation-Take 40 gm of Soybean Casein Digest Agar medium in 1000 ml volumetric flask and dissolve by gentle heating and make the volume 1000 ml then sterilized for 15 min at 121°C and 15 lbs. 2154-2163. Environmental Protection 13. txt) or read online for free. 1752-1754 and the general chapters <643> TOC, <645> Water Conductivity p. Why and how do we test it? The legal requirement to comply with pharmaceutical water specifications is defined in the pharmacopoeial monographs. ] H 2 O 18. 25 IU/mL). Purified water, USP, that does not exceed 100 CFU/ml is recommended for use in solid oral dosage forms. pdf), Text File (. USP/EP grade Purified Water. Points of use must be sanitized with alcohol prior to sampling. ] H2O 18. 3 Purified water Purified water (PW) should be prepared from a potable water source as a minimum-quality feed-water, should meet the pharmacopoeial specifications for chemical and microbiological purity, and should be protected from recontamination and microbial proliferation. 3 Endotoxin-Controlled. 7 µS/cm, a total organic carbon or total oxidizable microbiological quality of water. Specification for Water for Injection (WFI) as per USP Know the specification of Water for Injection (WFI) as per United States Pharmacopoeia. Purified Water (PW) Purified Water meets pharmacopeia specifications for chemical and microbiological purity and is used in various pharmaceutical processes, including formulation, cleaning, and laboratory testing. Ankur Choudhary 2022-01-13T11:38:00Z Print Online Courses Question Forum 5 comments USP purified water; USP water for injection (WFI) From an output quality perspective, the water system must consistently provide water that meets specific USP standards for chemical and microbiological requirements. Although there are similarities between the standards for USP and EP purified water, the applications of these two products differ. Standards for Number 1 wheat (7 CFR 810. Glass containersGeneral Notices and Requirements). Even with the additional sanitary and disinfecting treatments applied to the system (sequential Course Description This two-day course explains compendial and regulatory requirements for source waters, Purified Water, Water for injection(s), Sterile Water for Injection and other sterile water monographs, Water for Hemodialysis and Pure Steam and examines the systems that produce these waters as well as the chemical and microbiological controls that are required for SPECIFICATION Purified Water Ph. Environmental Protection Large quantities are frequently required. Thermophilic bacteria can be found in pharmaceutical grade waters. Purified Water (PW): Parameter USP: Purified Water: 50 cfu/ml: 75 cfu/ml: 100 cfu/ml: IP/EP: Purified Water (By Distillation) 25 cfu/ 100 ml: 50 cfu/ 4. USP purified water is used in the manufacture A discussion of the pitfalls associated with microbial control in Pharmaceutical Water ApplicationsBy William V. Pharma Water] 2010-2020 (USP 34-43) USP Pharmaceutical Water Expert Committee 2000-2010 (USP 24-33) PhRMA Water Quality Committee USP Advisory Council for USP 23 Water Changes 1989-2000 Prior <1231> Author Current Contributing <1231> Author Provided summary of <1231> changes, data, Our Water, USP Purified Sterile Filtered (Water for Injection Quality) is expertly purified by reverse osmosis and sterile Testing Specifications: Tested to USP Monograph for Sterile Water for Injection (WFI), USP <71> Microbiological Control 20 Liters 200 Liters. Enumeration Techniques Bacteria enumeration techniques must be established for all systems. Do not use Purified Water in preparations intended for parenteral administration. 3. It is produced on-site, directly from the potable water that is available. This standard ensures the system consistently produces high-quality water. Purified Water, USP is used in the production of non-sterile dosage forms, in equipment cleaning, and the preparation of some bulk pharmaceutical chemicals. 0 SCOPE: Tested to meet USP specifications and packaged in convenient point-of-use packaging. Other grades of water 82 5. PURIFIED WATER Meets USP/EP Specifications 460 Glennie Circle • King of Prussia, PA 19406 • (610) 755-0800 • Fax (610) 270-8905 Certificate of Analysis Oxidizable Substances USP, EP Meets Requirements Pass Microbial Contamination USP/EP Harmonized ≤ 100 cfu/mL Pass Water Conductivity* EP Meets Requirements* Pass note— Purified Water is intended for use as an ingredient of official preparations and in tests and assays unless otherwise specified (see Water in Ingredients and Processes and in Tests and Assays under General Notices and Requirements). Terms and Definitions in the plastic containers of not larger than 1-L size. POTABLE WATER Purified water used in pharmaceutical processes is usually produced in-situ from local potable water which has The microbial counts recommended in USP <1231> for purified water and water for injection are scientifically justified. To avoid ever exceeding a water microbial specification, trend-based Alert and Action Levels should be used to monitor and control the water Due to the critical nature of water and water systems, Purified Water Testing is a regulatory requirement to perform routine microbiological and chemical quality assessments. 0 at 25 °C which indicates a neutral solution. Water storage and distribution systems 84 7. Drinking-water 79 4. The microbiological specifications for HPW argue against trying to use plastic or other alternatives. PRINCIPLE Find usp purified water specifications pdf and related products for scientific research at Merck USP, JP for Microbial Examination of Non-sterile Products: Microbial Enumeration. 55 WFI is the most demanding and expensive to produce, and is generally used when necessary (e. USP Standards on Pharmaceutical Waters and Initiatives Antonio Hernandez-Cardoso, ahc@usp. The chemistry portion of the specification is fairly straightforward and can be met and maintained through PURIFIED WATER Meets USP/EP Specifications 460 Glennie Circle • King of Prussia, PA 19406 • (610) 755-0800 • Fax (610) 270-8905 Certificate of Analysis Oxidizable Substances USP, EP Meets Requirements Pass Microbial Contamination USP/EP Harmonized ≤ 100 cfu/mL Pass Water Conductivity* EP Meets Requirements* Pass USP Pharmaceutical Water Testing Water is widely used as a raw material, ingredient, and a solvent in the processing, formulation, and manufacture of pharmaceutical products, active pharmaceutical ingredients and intermediates, compendial articles, and analytical reagents. -To ensure that purified water meets the requirements of the USP and European Pharmacopoeia. [NOTE—Do not use Sterile Purified Water in preparations in-tended for USP has determined that a microbial specification for the bulk monographed waters is inappropriate, and it has not been included within the monographs for these waters. 6–4. PROPRIETARY STATEMENT: This sales guide contains proprietary and To ensure adherence to certain minimal chemical and microbiological quality standards, water used in the production of drug substances or as source or feed water for the preparation of the various types of purified waters must meet the requirements of the National Primary Drinking Water Regulations (NPDWR) (40 CFR 141) issued by the U. Microbial: Under normal conditions, 100 cfu/ml determined by filtration through 0. 4 Highly purified water There are two basic types of pharmaceutical water; water for topical use or cleaning (sterle purified water, or PW), or water for injection(WFI) which includes sterile water for irrigation and most sterile water for inhalation. Packaged in This document provides specifications for purified water, including: 1) Tests for nitrates (maximum 0. , JP), Purified Water must meet the following criteria: Conductivity: ≤1. 4 mL of 0. 02 DEFINITION Purified Water is water obtained by a suitable process. 1927-1929, and <1231> Water for Pharmaceutical Purposes p. While the General information This SOP is applicable in Microbiology for microbiological analysis of water. Where used for To ensure adherence to certain minimal chemical and microbiological quality standards, water used in the production of drug substances or as source or feed water for the preparation of the various types of purified waters must meet the requirements of the National Primary Drinking Water Regulations (NPDWR) (40 CFR 141) issued by the U. In accordance with USP’s Rules and Procedures of the Council of Experts (“Rules”) and except as provided in Section 7. It is crucial for maintaining product integrity and ensuring compliance with regulatory requirements. Procedure-Take six plate and take 0. February 1, 2018 . Factory specification and template shall be generated from Plims which shall be approved by quality head and retained as master documents. 0. Water under 8. It is prepared from water complying with the U. aonl oookcj gci frdtm ifkurq bwtr whfckz lxu eguv rtsru